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Established in 1993, the series Methods and Principles in Medicinal Chemistry has become a crucial source of information within the medicinal chemistry community and beyond. Authors and editors of the series come from pharmaceutical industry as well as from academic institutions, fostering a more active exchange between these domains. From the very beginning, the series focused on topical volumes covering hot concepts and technologies, and the reader will not miss any important topic in the field. The range of topics is as diverse as are the challenges facing modern drug developers, spanning the fields of organic chemistry, pharmacology, toxicology, life science, and analytics, the latter also including bioinformatics, chemoinformatics and proteomics.